Tolerability & Dosing

Tolerability & Dosing

Tolerability & Dosing

CLENPIQ
demonstrated
high patient compliance
and tolerability1*†

According to the validated Mayo Clinic Bowel Prep Tolerability Questionnaire1†:

99%

of patients completed the majority of the CLENPIQ prep‡

98%

are “mostly” or “somewhat willing” to take CLENPIQ again

90%

felt that the tolerability of CLENPIQ was “easy” or “acceptable”

Results demonstrated that patients had a high degree of tolerability and willingness to use CLENPIQ in the future

*Trial Design: The efficacy and safety of CLENPIQ were evaluated in a randomized, multicenter, controlled, assessor-blinded trial. CLENPIQ® (sodium picosulfate, magnesium oxide, and anhydrous citric acid) Oral Solution (SPMC) was administered in a split-dose regimen against an oral powder (for reconstitution) (P/MC powder) and efficacy was evaluated using 2 different measurement scales.1 In this trial, CLENPIQ patients were instructed to drink at least five 8-ounce glasses of clear liquid within 5 hours of the first dose of CLENPIQ and at least four 8-ounce glasses of clear liquid within 4 hours of the second dose.1

†The validated Mayo Clinic Bowel Prep Tolerability Questionnaire was administered to patients on the day of their colonoscopies prior to procedure to assess compliance and tolerability of bowel preparation.1

‡Majority was defined as <25% of the bowel prep remaining after dosing.1

Guidance for your patients taking CLENPIQ

This video is designed for your patient’s to provide them with information about how to successfully prepare for their colonoscopy with CLENPIQ.

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Drink, hydrate, repeat2

Hydration is an important part of your patient’s bowel prep and they should consume only clear liquids before their colonoscopy2,3

Night before3

5 PM to 9 PM

Your patient will take the first bottle of CLENPIQ
and drink five 8-ounce (oz) cups of water
between 5:00 PM and 9:00 PM the night
before their colonoscopy.

All liquids must be consumed over the next 5 hours.

Morning of3

5 hours before colonoscopy

Your patient will drink the second bottle
of CLENPIQ and four 8-ounce (oz) cups
or more of clear liquids.

Liquids must be finished 2 hours before colonoscopy or as you advise.

CLENPIQ Dosing Assistant

Recommend this tool to your patients so they can make their own CLENPIQ dosing schedule.

SEE DOSING ASSISTANT

Download easy-to-follow instructions for your patients taking split-dose CLENPIQ.

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Step-by-step split-dose administration

Dose 1 – On the day before the colonoscopy1:

  • Instruct patients to consume only clear liquids (no solid food or dairy) on the day before the colonoscopy up until 2 hours before the time of the colonoscopy
  • Take the first dose (1 bottle) of CLENPIQ during the evening before the colonoscopy (eg, 5:00 pm to 9:00 pm)
  • Follow CLENPIQ by drinking at least five 8-ounce cups (cup provided) of clear liquids within 5 hours and before bed
  • If severe bloating, distention, or abdominal pain occurs following the first dose, delay the second dose until the symptoms resolve

Dose 2 – Next morning on the day of the colonoscopy (start approximately 5 hours prior to colonoscopy)1:

  • Continue to consume only clear liquids (no solid food or dairy)
  • Take the second dose (the second bottle) of CLENPIQ
  • Following the CLENPIQ dose, drink at least three 8-ounce cups (cup provided) of clear liquids (24 ounces) at least 2 hours before the colonoscopy

Hydration is an important part of the prep
  • Water (plain or flavored)
  • Black coffee or tea (no milk, cream, soy, or nondairy creamer)
  • Clear broth or bouillon
  • Sports drinks (not red or purple)
  • Clear juices without pulp (such as apple juice or white grape juice)
  • Ginger ale and other sodas (not red or purple)
  • Plain Jell-O® (not red or purple)
  • Frozen juice bars (not red or purple)

Helpful CLENPIQ resources

A successful bowel prep is our goal with CLENPIQ. See these available resources to help you and your patients learn more about split-dose CLENPIQ and how to properly complete prep.

Instructions for Use

Clarity is priority for colonoscopies. Here are straightforward instructions to help you walk your patients through a bowel prep with CLENPIQ. 

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Watch and Learn

This video is a helpful tool to share with your patients to help explain step-by-step instructions for taking CLENPIQ.

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References: 1. Hookey L, Berliger G, Johnson II KL, Ayala J, Brogadir SP. Efficacy and safety of a ready-to-drink bowel preparation for colonoscopy: a randomized, controlled, non-inferiority trial. Therap Adv Gastroenterol. 2019;12:1756284819851510. 2. Lichtenstein GR, Cohen LB, Uribarri J. Review article: bowel preparation for colonoscopy–the importance of adequate hydration. Aliment Pharmacol Ther. 2007;26(5):633-641. 3. CLENPIQ®. Prescribing Information. Parsippany, NJ: Ferring Pharmaceuticals Inc; 2023.

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